Ontology highlight
ABSTRACT:
SUBMITTER: Gratias A
PROVIDER: S-EPMC2425466 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Gratias Ariane A Lepère Gersende G Garnier Olivier O Rosa Sarah S Duharcourt Sandra S Malinsky Sophie S Meyer Eric E Bétermier Mireille M
Nucleic acids research 20080417 10
Somatic genome assembly in the ciliate Paramecium involves the precise excision of thousands of short internal eliminated sequences (IESs) that are scattered throughout the germline genome and often interrupt open reading frames. Excision is initiated by double-strand breaks centered on the TA dinucleotides that are conserved at each IES boundary, but the factors that drive cleavage site recognition remain unknown. A degenerate consensus was identified previously at IES ends and genetic analyses ...[more]