Ontology highlight
ABSTRACT:
SUBMITTER: Park JY
PROVIDER: S-EPMC2425499 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Park Jung-Young JY Yoo Han-Wook HW Kim Bok-Ryang BR Park Raekil R Choi Sang-Yun SY Kim Youngho Y
Nucleic acids research 20080416 10
Rad51 plays a key role in the repair of DNA double-strand breaks through homologous recombination, which is the central process in the maintenance of genomic integrity. Five paralogs of the human Rad51 gene (hRad51) have been identified to date, including hRad51B, hRad51C, hRad51D, Xrcc2 and Xrcc3. In searches of additional hRad51 paralogs, we identified a novel hRad51 variant that lacked the sequence corresponding to exon 9 (hRad51-Deltaex9). The expected amino acid sequence of hRad51-Deltaex9 ...[more]