Ontology highlight
ABSTRACT:
SUBMITTER: Decha P
PROVIDER: S-EPMC2426624 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Decha Panita P Rungrotmongkol Thanyada T Intharathep Pathumwadee P Malaisree Maturos M Aruksakunwong Ornjira O Laohpongspaisan Chittima C Parasuk Vudhichai V Sompornpisut Pornthep P Pianwanit Somsak S Kokpol Sirirat S Hannongbua Supot S
Biophysical journal 20080328 1
The origin of the high pathogenicity of an emerging avian influenza H5N1 due to the -RRRKK- insertion at the cleavage loop of the hemagglutinin H5, was studied using the molecular dynamics technique, in comparison with those of the noninserted H5 and H3 bound to the furin (FR) active site. The cleavage loop of the highly pathogenic H5 was found to bind strongly to the FR cavity, serving as a conformation suitable for the proteolytic reaction. With this configuration, the appropriate interatomic ...[more]