Ontology highlight
ABSTRACT:
SUBMITTER: Qi J
PROVIDER: S-EPMC2426729 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Qi Jingzong J Gong Jingyi J Zhao Tongjin T Zhao Jie J Lam Penny P Ye Jing J Li John Zhong JZ Wu Jiawei J Zhou Hai-Meng HM Li Peng P
The EMBO journal 20080515 11
We previously showed that Cidea(-/-) mice are resistant to diet-induced obesity through the upregulation of energy expenditure. The AMP-activated protein kinase (AMPK), consisting of catalytic alpha subunit and regulatory subunits beta and gamma, has a pivotal function in energy homoeostasis. We show here that AMPK protein levels and enzymatic activity were significantly increased in the brown adipose tissue of Cidea(-/-) mice. We also found that Cidea is colocalized with AMPK in the endoplasmic ...[more]