Ontology highlight
ABSTRACT:
SUBMITTER: Higgins AW
PROVIDER: S-EPMC2427206 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Higgins Anne W AW Alkuraya Fowzan S FS Bosco Amy F AF Brown Kerry K KK Bruns Gail A P GA Donovan Diana J DJ Eisenman Robert R Fan Yanli Y Farra Chantal G CG Ferguson Heather L HL Gusella James F JF Harris David J DJ Herrick Steven R SR Kelly Chantal C Kim Hyung-Goo HG Kishikawa Shotaro S Korf Bruce R BR Kulkarni Shashikant S Lally Eric E Leach Natalia T NT Lemyre Emma E Lewis Janine J Ligon Azra H AH Lu Weining W Maas Richard L RL MacDonald Marcy E ME Moore Steven D P SD Peters Roxanna E RE Quade Bradley J BJ Quintero-Rivera Fabiola F Saadi Irfan I Shen Yiping Y Shendure Jay J Williamson Robin E RE Morton Cynthia C CC
American journal of human genetics 20080301 3
Apparently balanced chromosomal rearrangements in individuals with major congenital anomalies represent natural experiments of gene disruption and dysregulation. These individuals can be studied to identify novel genes critical in human development and to annotate further the function of known genes. Identification and characterization of these genes is the goal of the Developmental Genome Anatomy Project (DGAP). DGAP is a multidisciplinary effort that leverages the recent advances resulting fro ...[more]