Ontology highlight
ABSTRACT:
SUBMITTER: Hirose Y
PROVIDER: S-EPMC2427305 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Hirose Yuichiro Y Chiba Kazuhiro K Karasugi Tatsuki T Nakajima Masahiro M Kawaguchi Yoshiharu Y Mikami Yasuo Y Furuichi Tatsuya T Mio Futoshi F Miyake Atsushi A Miyamoto Takeshi T Ozaki Kouichi K Takahashi Atsushi A Mizuta Hiroshi H Kubo Toshikazu T Kimura Tomoatsu T Tanaka Toshihiro T Toyama Yoshiaki Y Ikegawa Shiro S
American journal of human genetics 20080501 5
Lumbar-disc herniation (LDH), one of the most common musculoskeletal diseases, has strong genetic determinants. Recently, several genes that encode extracellular matrix (ECM) proteins in the intervertebral disc have been reported to associate with LDH. Thrombospondins (THBSs) 1 and 2 are good candidates for the LDH susceptibility gene: They are intervertebral disc ECM proteins that regulate the effective levels of matrix metalloproteinases (MMPs) 2 and 9, which are key effectors of ECM remodelin ...[more]