Ontology highlight
ABSTRACT:
SUBMITTER: Zhang SL
PROVIDER: S-EPMC2427323 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Zhang Shenyuan L SL Kozak J Ashot JA Jiang Weihua W Yeromin Andriy V AV Chen Jing J Yu Ying Y Penna Aubin A Shen Wei W Chi Victor V Cahalan Michael D MD
The Journal of biological chemistry 20080417 25
We evaluated currents induced by expression of human homologs of Orai together with STIM1 in human embryonic kidney cells. When co-expressed with STIM1, Orai1 induced a large inwardly rectifying Ca(2+)-selective current with Ca(2+)-induced slow inactivation. A point mutation of Orai1 (E106D) altered the ion selectivity of the induced Ca(2+) release-activated Ca(2+) (CRAC)-like current while retaining an inwardly rectifying I-V characteristic. Expression of the C-terminal portion of STIM1 with Or ...[more]