Ontology highlight
ABSTRACT:
SUBMITTER: Shen C
PROVIDER: S-EPMC2427353 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Shen Chengyong C Chen Yongfeng Y Liu Huaqing H Zhang Kejing K Zhang Ting T Lin Anning A Jing Naihe N
The Journal of biological chemistry 20080423 25
Accumulation of senile plaques composed of amyloid beta-peptide (Abeta) is a pathological hallmark of Alzheimer disease (AD), and Abeta is generated through the sequential cleavage of amyloid precursor protein (APP) by beta- and gamma-secretase. Although oxidative stress has been implicated in the AD pathogenesis by inducing Abeta production, the underlying mechanism remains elusive. Here we show that the pro-oxidant H(2)O(2) promotes Abeta production through c-Jun N-terminal kinase (JNK)-depend ...[more]