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Switching of chromatin-remodelling complexes for oestrogen receptor-alpha.


ABSTRACT: The female sex steroid hormone oestrogen stimulates both cell proliferation and cell differentiation in target tissues. These biological actions are mediated primarily through nuclear oestrogen receptors (ERs). The ligand-dependent transactivation of ERs requires several nuclear co-regulator complexes; however, the cell-cycle-dependent associations of these complexes are poorly understood. By using a synchronization system, we found that the transactivation function of ERalpha at G2/M was lowered. Biochemical approaches showed that ERalpha associated with two discrete classes of ATP-dependent chromatin-remodelling complex in a cell-cycle-dependent manner. The components of the NuRD-type complex were identified as G2/M-phase-specific ERalpha co-repressors. Thus, our results indicate that the transactivation function of ERalpha is cell-cycle dependent and is coupled with a cell-cycle-dependent association of chromatin-remodelling complexes.

SUBMITTER: Okada M 

PROVIDER: S-EPMC2427383 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature

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Switching of chromatin-remodelling complexes for oestrogen receptor-alpha.

Okada Maiko M   Takezawa Shin-ichiro S   Mezaki Yoshihiro Y   Yamaoka Ikuko I   Takada Ichiro I   Kitagawa Hirochika H   Kato Shigeaki S  

EMBO reports 20080502 6


The female sex steroid hormone oestrogen stimulates both cell proliferation and cell differentiation in target tissues. These biological actions are mediated primarily through nuclear oestrogen receptors (ERs). The ligand-dependent transactivation of ERs requires several nuclear co-regulator complexes; however, the cell-cycle-dependent associations of these complexes are poorly understood. By using a synchronization system, we found that the transactivation function of ERalpha at G2/M was lowere  ...[more]

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