Ontology highlight
ABSTRACT:
SUBMITTER: Okada M
PROVIDER: S-EPMC2427383 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Okada Maiko M Takezawa Shin-ichiro S Mezaki Yoshihiro Y Yamaoka Ikuko I Takada Ichiro I Kitagawa Hirochika H Kato Shigeaki S
EMBO reports 20080502 6
The female sex steroid hormone oestrogen stimulates both cell proliferation and cell differentiation in target tissues. These biological actions are mediated primarily through nuclear oestrogen receptors (ERs). The ligand-dependent transactivation of ERs requires several nuclear co-regulator complexes; however, the cell-cycle-dependent associations of these complexes are poorly understood. By using a synchronization system, we found that the transactivation function of ERalpha at G2/M was lowere ...[more]