Interleukin 9: a candidate gene for asthma.
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ABSTRACT:
SUBMITTER: Nicolaides NC
PROVIDER: S-EPMC24282 | biostudies-literature | 1997 Nov
REPOSITORIES: biostudies-literature
Publications
Interleukin 9: a candidate gene for asthma.
Nicolaides N C NC Holroyd K J KJ Ewart S L SL Eleff S M SM Kiser M B MB Dragwa C R CR Sullivan C D CD Grasso L L Zhang L Y LY Messler C J CJ Zhou T T Kleeberger S R SR Buetow K H KH Levitt R C RC
Proceedings of the National Academy of Sciences of the United States of America 19971101 24
Asthma is a complex heritable inflammatory disorder of the airways associated with clinical signs of atopy and bronchial hyperresponsiveness. Recent studies localized a major gene for asthma to chromosome 5q31-q33 in humans. Thus, this segment of the genome represents a candidate region for genes that determine susceptibility to bronchial hyperresponsiveness and atopy in animal models. Homologs of candidate genes on human chromosome 5q31-q33 are found in four regions in the mouse genome, two on ...[more]
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