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The tachykinin receptor 3 is associated with alcohol and cocaine dependence.

ABSTRACT: A broad region on chromosome 4q was previously linked to the phenotype of alcohol dependence in the Collaborative Study on the Genetics of Alcoholism sample. A strong positional candidate gene was identified within this region: tachykinin receptor 3 gene (TACR3), which encodes tachykinin receptor 3 (NK3R), the receptor for the tachykinin 3 (neurokinin B) peptide. Pharmacological studies have provided evidence that the administration of NK3R agonists attenuates the intake of alcohol and NK3R can also mediate the acute and chronic behavioral effects of cocaine.Thirty SNPs were genotyped throughout TACR3. Family based association analysis was performed in 219 European American families to detect an association with alcohol dependence. Subsequent analyses were performed to evaluate the evidence of association with other definitions of alcohol dependence as well as cocaine dependence.Seven of the 9 SNPs in the 3' region of TACR3 provided significant evidence of association with alcohol dependence (p

SUBMITTER: Foroud T 

PROVIDER: S-EPMC2430628 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature

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The tachykinin receptor 3 is associated with alcohol and cocaine dependence.

Foroud Tatiana T   Wetherill Leah Flury LF   Kramer John J   Tischfield Jay A JA   Nurnberger John I JI   Schuckit Marc A MA   Xuei Xiaoling X   Edenberg Howard J HJ  

Alcoholism, clinical and experimental research 20080415 6

<h4>Background</h4>A broad region on chromosome 4q was previously linked to the phenotype of alcohol dependence in the Collaborative Study on the Genetics of Alcoholism sample. A strong positional candidate gene was identified within this region: tachykinin receptor 3 gene (TACR3), which encodes tachykinin receptor 3 (NK3R), the receptor for the tachykinin 3 (neurokinin B) peptide. Pharmacological studies have provided evidence that the administration of NK3R agonists attenuates the intake of al  ...[more]

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