Ontology highlight
ABSTRACT:
SUBMITTER: Stoecklin G
PROVIDER: S-EPMC2431067 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Stoecklin Georg G Tenenbaum Scott A SA Mayo Thomas T Chittur Sridar V SV George Ajish D AD Baroni Timothy E TE Blackshear Perry J PJ Anderson Paul P
The Journal of biological chemistry 20080206 17
Tristetraprolin (TTP) is an RNA-binding protein required for the rapid degradation of mRNAs containing AU-rich elements. Targets regulated by TTP include the mRNAs encoding tumor necrosis factor-alpha, granulocyte-macrophage colony-stimulating factor, interleukin-2 (IL-2), and immediate early response 3. To identify novel target mRNAs of TTP in macrophages, we used a genome-wide approach that combines RNA immunoprecipitation and microarray analysis. A list was compiled of 137 mRNAs that are asso ...[more]