Ontology highlight
ABSTRACT:
SUBMITTER: Wei CC
PROVIDER: S-EPMC2431086 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Wei Chin-Chuan CC Wang Zhi-Qiang ZQ Tejero Jesús J Yang Ya-Ping YP Hemann Craig C Hille Russ R Stuehr Dennis J DJ
The Journal of biological chemistry 20080218 17
Nitric-oxide synthases (NOS) are catalytically self-sufficient flavo-heme enzymes that generate NO from arginine (Arg) and display a novel utilization of their tetrahydrobiopterin (H(4)B) cofactor. During Arg hydroxylation, H(4)B acts as a one-electron donor and is then presumed to redox cycle (i.e. be reduced back to H(4)B) within NOS before further catalysis can proceed. Whereas H(4)B radical formation is well characterized, the subsequent presumed radical reduction has not been demonstrated, ...[more]