Ontology highlight
ABSTRACT:
SUBMITTER: Cha SC
PROVIDER: S-EPMC2431127 | biostudies-literature | 2006 May
REPOSITORIES: biostudies-literature
Cha Soung-Chul SC Kwak Larry W LW Ruffini Pier Adelchi PA Qin Hong H Neelapu Sattva S Biragyn Arya A
Journal of immunological methods 20060331 1-2
Active immunization of follicular lymphoma patients with idiotypic vaccines elicits antigen-specific antibody responses, T-cell responses, and antitumor effects. We hypothesized that these vaccinated patients could generate tumor-specific immune responses, not only against idiotype, but also against other tumor-associated antigens (TAA) by a mechanism of epitope spreading. To identify potential antigens, a phage surface expressed cDNA library derived from primary tumor cells was screened with se ...[more]