Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt.
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ABSTRACT:
SUBMITTER: Fulco M
PROVIDER: S-EPMC2431467 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
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Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt.
Fulco Marcella M Cen Yana Y Zhao Po P Hoffman Eric P EP McBurney Michael W MW Sauve Anthony A AA Sartorelli Vittorio V
Developmental cell 20080501 5
It is intuitive to speculate that nutrient availability may influence differentiation of mammalian cells. Nonetheless, a comprehensive complement of the molecular determinants involved in this process has not been elucidated yet. Here, we have investigated how nutrients (glucose) affect skeletal myogenesis. Glucose restriction (GR) impaired differentiation of skeletal myoblasts and was associated with activation of the AMP-activated protein kinase (AMPK). Activated AMPK was required to promote G ...[more]
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