Ontology highlight
ABSTRACT:
SUBMITTER: Mulder J
PROVIDER: S-EPMC2438381 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Mulder Jan J Aguado Tania T Keimpema Erik E Barabás Klaudia K Ballester Rosado Carlos J CJ Nguyen Laurent L Monory Krisztina K Marsicano Giovanni G Di Marzo Vincenzo V Hurd Yasmin L YL Guillemot Francois F Mackie Ken K Lutz Beat B Guzmán Manuel M Lu Hui-Chen HC Galve-Roperh Ismael I Harkany Tibor T
Proceedings of the National Academy of Sciences of the United States of America 20080618 25
Endocannabinoids (eCBs) have recently been identified as axon guidance cues shaping the connectivity of local GABAergic interneurons in the developing cerebrum. However, eCB functions during pyramidal cell specification and establishment of long-range axonal connections are unknown. Here, we show that eCB signaling is operational in subcortical proliferative zones from embryonic day 12 in the mouse telencephalon and controls the proliferation of pyramidal cell progenitors and radial migration of ...[more]