Ontology highlight
ABSTRACT:
SUBMITTER: Delva E
PROVIDER: S-EPMC2440613 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Delva Emmanuella E Jennings Jean Marie JM Calkins Cathárine C CC Kottke Margaret D MD Faundez Victor V Kowalczyk Andrew P AP
The Journal of biological chemistry 20080423 26
Pemphigus vulgaris (PV) is a life-threatening autoimmune disease characterized by oral mucosal erosions and epidermal blistering. The autoantibodies generated target the desmosomal cadherin desmoglein-3 (Dsg3). Previous studies demonstrate that upon PV IgG binding, Dsg3 is internalized and enters an endo-lysosomal pathway where it is degraded. To define the endocytic machinery involved in PV IgG-induced Dsg3 internalization, human keratinocytes were incubated with PV IgG, and various tools were ...[more]