Ontology highlight
ABSTRACT:
SUBMITTER: Hazy TE
PROVIDER: S-EPMC2440774 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Hazy Thomas E TE Frank Michael J MJ O'reilly Randall C RC
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20070901 1485
The prefrontal cortex (PFC) has long been thought to serve as an 'executive' that controls the selection of actions and cognitive functions more generally. However, the mechanistic basis of this executive function has not been clearly specified often amounting to a homunculus. This paper reviews recent attempts to deconstruct this homunculus by elucidating the precise computational and neural mechanisms underlying the executive functions of the PFC. The overall approach builds upon existing mech ...[more]