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Laforin confers cancer resistance to energy deprivation-induced apoptosis.

ABSTRACT: A long-standing but poorly understood observation in experimental cancer therapy is the heterogeneity in cancer susceptibility to energy deprivation. Here, we show that the hexose kinase inhibitor 2-deoxyglucose (2-dG) preferentially kills cancer cells with defective laforin expression and significantly increases the survival of mice with aggressive lymphoma due to a genetic defect of the laforin-encoding Epm2a gene. Normal cells from Epm2a(-/-) mice also had greatly increased susceptibility to 2-dG. Thus, laforin is a novel regulator for cellular response to energy deprivation and its defects in cancer cells may be targeted for cancer therapy.

SUBMITTER: Wang Y

PROVIDER: S-EPMC2440919 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature

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Laforin confers cancer resistance to energy deprivation-induced apoptosis.

Wang Yin Y Liu Yan Y Wu Cindy C McNally Beth B Liu Yang Y Zheng Pan P

Cancer research 20080601 11

A long-standing but poorly understood observation in experimental cancer therapy is the heterogeneity in cancer susceptibility to energy deprivation. Here, we show that the hexose kinase inhibitor 2-deoxyglucose (2-dG) preferentially kills cancer cells with defective laforin expression and significantly increases the survival of mice with aggressive lymphoma due to a genetic defect of the laforin-encoding Epm2a gene. Normal cells from Epm2a(-/-) mice also had greatly increased susceptibility to ...[more]

PMID: 18519661

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