Ontology highlight
ABSTRACT:
SUBMITTER: Zhang ZM
PROVIDER: S-EPMC2441563 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Zhang Ziwei M ZM Simmerman Joseph A JA Guibao Cristina D CD Zheng Jie J JJ
The Journal of biological chemistry 20080430 27
The G protein-coupled receptor kinase-interacting protein 1 (GIT1) is a multidomain protein that plays an important role in cell adhesion, motility, cytoskeletal remodeling, and membrane trafficking. GIT1 mediates the localization of the p21-activated kinase (PAK) and PAK-interactive exchange factor to focal adhesions, and its activation is regulated by the interaction between its C-terminal paxillin-binding domain (PBD) and the LD motifs of paxillin. In this study, we determined the solution st ...[more]