Synthetic libraries of tyrosine-derived bacterial metabolites.
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ABSTRACT:
SUBMITTER: Georgiades SN
PROVIDER: S-EPMC2441646 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Publications
Synthetic libraries of tyrosine-derived bacterial metabolites.
Georgiades Savvas N SN Clardy Jon J
Bioorganic & medicinal chemistry letters 20071022 10
The preparation of a collection of 131 small molecules, reminiscent of families of long chain N-acyl tyrosines, enamides and enol esters that have been isolated from heterologous expression of environmental DNA (eDNA) in Escherichia coli, is reported. The synthetic libraries of N-acyl tyrosines and their 3-keto counterparts were prepared via solid-phase routes, whereas the enamides and enol esters were synthesized in solution-phase. ...[more]
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