Ontology highlight
ABSTRACT:
SUBMITTER: Smeenk L
PROVIDER: S-EPMC2441782 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Smeenk Leonie L van Heeringen Simon J SJ Koeppel Max M van Driel Marc A MA Bartels Stefanie J J SJ Akkers Robert C RC Denissov Sergei S Stunnenberg Hendrik G HG Lohrum Marion M
Nucleic acids research 20080512 11
The tumor suppressor p53 is a sequence-specific transcription factor, which regulates the expression of target genes involved in different stress responses. To understand p53's essential transcriptional functions, unbiased analysis of its DNA-binding repertoire is pivotal. In a genome-wide tiling ChIP-on-chip approach, we have identified and characterized 1546 binding sites of p53 upon Actinomycin D treatment. Among those binding sites were known as well as novel p53 target sites, which included ...[more]