Ontology highlight
ABSTRACT:
SUBMITTER: Ng KK
PROVIDER: S-EPMC2441838 | biostudies-literature | 2008
REPOSITORIES: biostudies-literature
Ng Kenneth K S KK Arnold Jamie J JJ Cameron Craig E CE
Current topics in microbiology and immunology 20080101
RNA-dependent RNA polymerases (RdRPs) play key roles in viral transcription and genome replication, as well as epigenetic and post-transcriptional control of cellular gene expression. In this article, we review the crystallographic, biochemical, and molecular genetic data available for viral RdRPs that have led to a detailed description of substrate and cofactor binding, fidelity of nucleotide selection and incorporation, and catalysis. It is likely that the cellular RdRPs will share some of the ...[more]