Identification of a common gene expression response in different lung inflammatory diseases in rodents and macaques.
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ABSTRACT:
SUBMITTER: Pennings JL
PROVIDER: S-EPMC2442866 | biostudies-literature | 2008
REPOSITORIES: biostudies-literature
Publications
Identification of a common gene expression response in different lung inflammatory diseases in rodents and macaques.
Pennings Jeroen L A JL Kimman Tjeerd G TG Janssen Riny R
PloS one 20080709 7
To identify gene expression responses common to multiple pulmonary diseases we collected microarray data for acute lung inflammation models from 12 studies and used these in a meta-analysis. The data used include exposures to air pollutants; bacterial, viral, and parasitic infections; and allergic asthma models. Hierarchical clustering revealed a cluster of 383 up-regulated genes with a common response. This cluster contained five subsets, each characterized by more specific functions such as in ...[more]
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