Plasminogen activator inhibitor-1 4G/5G gene polymorphism and primary open-angle glaucoma.

ABSTRACT:

Purpose

Alterations of the plasmin system have been suggested to participate in the multifactorial pathogenesis of primary open-angle glaucoma (POAG). The main physiological inhibitor of the plasmin system is plasminogen activator inhibitor-1 (PAI-1), which leads to decreased degradation of extracellular material. Interestingly, elevated PAI-1 levels in the aqueous humor of patients with POAG have been reported. A common polymorphism within the promoter region (PAI-1 4G/5G) has previously been shown to reduce the gene transcription rate of PAI-1. The purpose of the present study was to investigate a hypothesized association between PAI-1 4G/5G and the presence of POAG in a Caucasian population.

Methods

The present case-control study comprised 212 unrelated patients with POAG

SUBMITTER: Mossbock G 

PROVIDER: S-EPMC2443753 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature