Impact of mycophenolic acid on the functionality of human polymorphonuclear neutrophils and dendritic cells during interaction with Aspergillus fumigatus.
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ABSTRACT:
SUBMITTER: Mezger M
PROVIDER: S-EPMC2443887 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Publications
Impact of mycophenolic acid on the functionality of human polymorphonuclear neutrophils and dendritic cells during interaction with Aspergillus fumigatus.
Mezger Markus M Wozniok Iwona I Blockhaus Christian C Kurzai Oliver O Hebart Holger H Einsele Hermann H Loeffler Juergen J
Antimicrobial agents and chemotherapy 20080421 7
Mycophenolic acid (MPA) is used clinically to prevent graft rejection but may increase the risk of fungal infection. We observed that MPA enhanced the Aspergillus fumigatus-induced oxidative burst of polymorphonuclear neutrophils, but without a corresponding increase in fungal killing. Furthermore, MPA inhibited the proinflammatory cytokine response and maturation of dendritic cells. ...[more]
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