Ontology highlight
ABSTRACT:
SUBMITTER: Delalande JM
PROVIDER: S-EPMC2443937 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Developmental dynamics : an official publication of the American Association of Anatomists 20080401 4
Smad-interacting protein-1 (SIP1) has been implicated in the development of Mowat-Wilson syndrome whose patients exhibit Hirschsprung disease, an aganglionosis of the large intestine, as well as other phenotypes. We have identified and cloned two sip1 orthologues in zebrafish. Both sip1 orthologues are expressed maternally and have dynamic zygotic expression patterns that are temporally and spatially distinct. We have investigated the function of both orthologues using translation and splice-blo ...[more]