Ontology highlight
ABSTRACT:
SUBMITTER: Cingolani LA
PROVIDER: S-EPMC2446609 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Cingolani Lorenzo A LA Thalhammer Agnes A Yu Lily M Y LM Catalano Myriam M Ramos Timothy T Colicos Michael A MA Goda Yukiko Y
Neuron 20080601 5
At synapses, cell adhesion molecules (CAMs) provide the molecular framework for coordinating signaling events across the synaptic cleft. Among synaptic CAMs, the integrins, receptors for extracellular matrix proteins and counterreceptors on adjacent cells, are implicated in synapse maturation and plasticity and memory formation. However, little is known about the molecular mechanisms of integrin action at central synapses. Here, we report that postsynaptic beta3 integrins control synaptic streng ...[more]