Ontology highlight
ABSTRACT:
SUBMITTER: Schuijt TJ
PROVIDER: S-EPMC2446733 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Schuijt Tim J TJ Hovius Joppe W R JW van Burgel Nathalie D ND Ramamoorthi Nandhini N Fikrig Erol E van Dam Alje P AP
Infection and immunity 20080421 7
Borrelia burgdorferi, the agent of Lyme disease, is transmitted by ticks. During transmission from the tick to the host, spirochetes are delivered with tick saliva, which contains the salivary protein Salp15. Salp15 has been shown to protect spirochetes against B. burgdorferi-specific antibodies. We now show that Salp15 from both Ixodes ricinus and Ixodes scapularis protects serum-sensitive isolates of Borrelia burgdorferi sensu lato against complement-mediated killing. I. ricinus Salp15 showed ...[more]