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Outbreak of OXY-2-Producing Klebsiella oxytoca in a renal transplant unit.


ABSTRACT: We describe a Klebsiella oxytoca infection outbreak in a renal transplant unit that involved seven patients. All strains belonged to a single pulsed-field gel electrophoresis pattern and were resistant to amoxicillin-clavulanate, cefuroxime, piperacillin-tazobactam, and aztreonam but susceptible to ceftriaxone, ceftazidime, cefepime, and imipenem. Chromosomal beta-lactamase hyperproduction was caused by a point mutation in the bla(OXY-2) gene promoter region.

SUBMITTER: Zarate MS 

PROVIDER: S-EPMC2446844 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature

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Outbreak of OXY-2-Producing Klebsiella oxytoca in a renal transplant unit.

Zárate Mariela Soledad MS   Gales Ana C AC   Picão Renata C RC   Pujol Gervasio Soler GS   Lanza Alejandra A   Smayevsky Jorgelina J  

Journal of clinical microbiology 20080416 6


We describe a Klebsiella oxytoca infection outbreak in a renal transplant unit that involved seven patients. All strains belonged to a single pulsed-field gel electrophoresis pattern and were resistant to amoxicillin-clavulanate, cefuroxime, piperacillin-tazobactam, and aztreonam but susceptible to ceftriaxone, ceftazidime, cefepime, and imipenem. Chromosomal beta-lactamase hyperproduction was caused by a point mutation in the bla(OXY-2) gene promoter region. ...[more]

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