Ontology highlight
ABSTRACT:
SUBMITTER: Bandaranayake RM
PROVIDER: S-EPMC2447101 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Journal of virology 20080423 13
The effect of amino acid variability between human immunodeficiency virus type 1 (HIV-1) clades on structure and the emergence of resistance mutations in HIV-1 protease has become an area of significant interest in recent years. We determined the first crystal structure of the HIV-1 CRF01_AE protease in complex with the p1-p6 substrate to a resolution of 2.8 A. Hydrogen bonding between the flap hinge and the protease core regions shows significant structural rearrangements in CRF01_AE protease c ...[more]