Ontology highlight
ABSTRACT:
SUBMITTER: Foley CJ
PROVIDER: S-EPMC2447132 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Foley Caitlin J CJ Freedman Holly H Choo Sheryl L SL Onyskiw Christina C Fu Nai Yang NY Yu Victor C VC Tuszynski Jack J Pratt Joanne C JC Baksh Shairaz S
Molecular and cellular biology 20080512 14
RASSF1A is a tumor suppressor protein involved in death receptor-dependent apoptosis utilizing the Bax-interacting protein MOAP-1 (previously referred to as MAP-1). However, the dynamics of death receptor recruitment of RASSF1A and MOAP-1 are still not understood. We have now detailed recruitment to death receptors (tumor necrosis factor receptor 1 [TNF-R1] and TRAIL-R1/DR4) and identified domains of RASSF1A and MOAP-1 that are required for death receptor interaction. Upon TNF-alpha stimulation, ...[more]