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PFlexAna: detecting conformational changes in remotely related proteins.

ABSTRACT: The pFlexAna (protein flexibility analyzer) web server detects and displays conformational changes in remotely related proteins, without relying on sequence homology. To do so, it first applies a reliable statistical test to align core protein fragments that are structurally similar and then clusters these aligned fragment pairs into 'super-alignments', according to the similarity of geometric transformations that align them. The result is that the dominant conformational changes occur between the clusters, while the smaller conformational changes occur within a cluster. pFlexAna is available at http://bigbird.comp.nus.edu.sg/pfa2/.

SUBMITTER: Nigham A

PROVIDER: S-EPMC2447781 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature

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pFlexAna: detecting conformational changes in remotely related proteins.

Nigham Anshul A Tucker-Kellogg Lisa L Mihalek Ivana I Verma Chandra C Hsu David D

Nucleic acids research 20080513 Web Server issue

The pFlexAna (protein flexibility analyzer) web server detects and displays conformational changes in remotely related proteins, without relying on sequence homology. To do so, it first applies a reliable statistical test to align core protein fragments that are structurally similar and then clusters these aligned fragment pairs into 'super-alignments', according to the similarity of geometric transformations that align them. The result is that the dominant conformational changes occur between t ...[more]

PMID: 18477634

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