Ontology highlight
ABSTRACT:
SUBMITTER: Laan L
PROVIDER: S-EPMC2449340 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Laan Liedewij L Husson Julien J Munteanu E Laura EL Kerssemakers Jacob W J JW Dogterom Marileen M
Proceedings of the National Academy of Sciences of the United States of America 20080624 26
Individual dynamic microtubules can generate pushing or pulling forces when their growing or shrinking ends are in contact with cellular objects such as the cortex or chromosomes. These microtubules can operate in parallel bundles, for example when interacting with mitotic chromosomes. Here, we investigate the force-generating capabilities of a bundle of growing microtubules and study the effect that force has on the cooperative dynamics of such a bundle. We used an optical tweezers setup to stu ...[more]