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A genome-wide view of the spectrum of spontaneous mutations in yeast.

ABSTRACT: The mutation process ultimately defines the genetic features of all populations and, hence, has a bearing on a wide range of issues involving evolutionary genetics, inheritance, and genetic disorders, including the predisposition to cancer. Nevertheless, formidable technical barriers have constrained our understanding of the rate at which mutations arise and the molecular spectrum of their effects. Here, we report on the use of complete-genome sequencing in the characterization of spontaneously arising mutations in the yeast Saccharomyces cerevisiae. Our results confirm some findings previously obtained by indirect methods but also yield numerous unexpected findings, in particular a very high rate of point mutation and skewed distribution of base-substitution types in the mitochondrion, a very high rate of segmental duplication and deletion in the nuclear genome, and substantial deviations in the mutational profile among various model organisms.

SUBMITTER: Lynch M 

PROVIDER: S-EPMC2453693 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature

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A genome-wide view of the spectrum of spontaneous mutations in yeast.

Lynch Michael M   Sung Way W   Morris Krystalynne K   Coffey Nicole N   Landry Christian R CR   Dopman Erik B EB   Dickinson W Joseph WJ   Okamoto Kazufusa K   Kulkarni Shilpa S   Hartl Daniel L DL   Thomas W Kelley WK  

Proceedings of the National Academy of Sciences of the United States of America 20080626 27

The mutation process ultimately defines the genetic features of all populations and, hence, has a bearing on a wide range of issues involving evolutionary genetics, inheritance, and genetic disorders, including the predisposition to cancer. Nevertheless, formidable technical barriers have constrained our understanding of the rate at which mutations arise and the molecular spectrum of their effects. Here, we report on the use of complete-genome sequencing in the characterization of spontaneously  ...[more]

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