Cluster analysis and display of genome-wide expression patterns.
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ABSTRACT:
SUBMITTER: Eisen MB
PROVIDER: S-EPMC24541 | biostudies-literature | 1998 Dec
REPOSITORIES: biostudies-literature
Publications
Cluster analysis and display of genome-wide expression patterns.
Eisen M B MB Spellman P T PT Brown P O PO Botstein D D
Proceedings of the National Academy of Sciences of the United States of America 19981201 25
A system of cluster analysis for genome-wide expression data from DNA microarray hybridization is described that uses standard statistical algorithms to arrange genes according to similarity in pattern of gene expression. The output is displayed graphically, conveying the clustering and the underlying expression data simultaneously in a form intuitive for biologists. We have found in the budding yeast Saccharomyces cerevisiae that clustering gene expression data groups together efficiently genes ...[more]
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