Ontology highlight
ABSTRACT:
SUBMITTER: Griffin CT
PROVIDER: S-EPMC2459551 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Griffin Courtney T CT Brennan Jennifer J Magnuson Terry T
Development (Cambridge, England) 20071219 3
ATP-dependent chromatin-remodeling complexes contribute to the proper temporal and spatial patterns of gene expression in mammalian embryos and therefore play important roles in a number of developmental processes. SWI/SNF-like chromatin-remodeling complexes use one of two different ATPases as their catalytic subunit: brahma (BRM, also known as SMARCA2) and brahma-related gene 1 (BRG1, also known as SMARCA4). We have conditionally deleted a floxed Brg1 allele with a Tie2-Cre transgene, which is ...[more]