Dataset Information

Systematic review of the fetal effects of prenatal binge-drinking.

ABSTRACT:

Objective

The effects of binge-drinking during pregnancy on the fetus and child have been an increasing concern for clinicians and policy-makers. This study reviews the available evidence from human observational studies.

Design

Systematic review of observational studies.

Population

Pregnant women or women who are trying to become pregnant.

Methods

A computerised search strategy was run in Medline, Embase, Cinahl and PsychInfo for the years 1970-2005. Titles and abstracts were read by two researchers for eligibility. Eligible papers were then obtained and read in full by two researchers to decide on inclusion. The papers were assessed for quality using the Newcastle-Ottawa Quality Assessment Scales and data were extracted.

Main outcome measures

Adverse outcomes considered in this study included miscarriage; stillbirth; intrauterine growth restriction; prematurity; birth-weight; small for gestational age at birth; and birth defects, including fetal alcohol syndrome and neurodevelopmental effects.

Results

The search resulted in 3630 titles and abstracts, which were narrowed down to 14 relevant papers. There were no consistently significant effects of alcohol on any of the outcomes considered. There was a possible effect on neurodevelopment. Many of the reported studies had methodological weaknesses despite being assessed as having reasonable quality.

Conclusions

This systematic review found no convincing evidence of adverse effects of prenatal binge-drinking, except possibly on neurodevelopmental outcomes.

SUBMITTER: Henderson J

PROVIDER: S-EPMC2465662 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Systematic review of the fetal effects of prenatal binge-drinking.

Henderson Jane J Kesmodel Ulrik U Gray Ron R

Journal of epidemiology and community health 20071201 12

<h4>Objective</h4>The effects of binge-drinking during pregnancy on the fetus and child have been an increasing concern for clinicians and policy-makers. This study reviews the available evidence from human observational studies.<h4>Design</h4>Systematic review of observational studies.<h4>Population</h4>Pregnant women or women who are trying to become pregnant.<h4>Methods</h4>A computerised search strategy was run in Medline, Embase, Cinahl and PsychInfo for the years 1970-2005. Titles and abst ...[more]

PMID: 18000129

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Project description:IntroductionBinge drinking is the most common pattern of alcohol use among young people in Western countries. Adolescence and young adulthood is a vulnerable developmental period and binge drinking during this time has a higher potential for neurotoxicity and interference with ongoing neural and cognitive development. The purpose of this systematic review will be to assess and integrate evidence of the impact of binge drinking on cognition, brain structure and function in youth aged 10-24 years. Cross-sectional studies will synthesise the aberrations associated with binge drinking, while longitudinal studies will distinguish the cognitive and neural antecedents from the cognitive and neural effects that are a consequence of binge drinking.Methods and analysisA total of five peer-reviewed databases (PubMed, EMBASE, Medline, PsychINFO, ProQuest) will be systematically searched and the search period will include all studies published prior to 1 April 2018. The search terms will be a combination of MeSH keywords that are based on previous relevant reviews. Study selection will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and study quality will be assessed using The Grades of Recommendation, Assessment, Development and Evaluation approach. All studies will be screened against eligibility criteria designed to synthesise studies that examined a young binge drinking sample and used neuropsychological, neurophysiological or neuroimaging assessment techniques. Studies will be excluded if participants were significantly involved in other substances or if they had been clinically diagnosed with an alcohol use disorder, or any psychiatric, neurological or pharmacological condition. If available data permits, a meta-analysis will be conducted.Ethics and disseminationFormal ethics approval is not required as primary data will not be collected. The results will be disseminated through a peer-reviewed publication, conference presentations and social media.Trial registration numberInternational Prospective Register for Systematic Reviews (PROSPERO) number: CRD42018086856.

Project description:BackgroundAlcohol use is the behaviour that has the most significant impact on the mortality and morbidity of young people, and binge drinking is becoming the norm among this population. The burden of disease of binge drinking during adolescence and young adulthood is significant and warrants the development of effective prevention strategies. Although the literature on risk factors for excessive substance use has been increasing, to our knowledge, a systematic review of the factors associated with binge drinking among young people has not yet been conducted. This study aims to identify and organise the factors associated with binge drinking among young people aged 15 to 24 years; and to provide a framework to further understand these factors in order to better target prevention strategies.Methods/designThis systematic review of the literature will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations. The databases PubMed, Embase, PsycINFO and Social Care will be searched for articles published between 1 January 2006 and 31 December 2015. Our search focuses on studies examining the risk factors for binge drinking among young people (between the ages of 15 and 24). Observational studies (cross-sectional, cohort and case-control studies) will be included, while randomised controlled trials will be excluded. Case series and case reports will also be excluded, while reviews, if relevant, will be included. The primary outcome is binge drinking. Secondary outcomes include indicators of frequency and consequences of binge drinking. Two reviewers will independently screen articles, extract relevant data and assess the quality of the studies.DiscussionThis systematic review will add to our knowledge and understanding of binge drinking among young people. It will allow us to identify the main risk and protective factors associated with binge drinking among this population and ultimately help to define the lines for further investigation and research, as an important part of prevention strategies in this area of work.Systematic review registrationThis protocol is registered in the PROSPERO registry of the University of York (reference number: CRD42016032496 ).

Dataset Information

Systematic review of the fetal effects of prenatal binge-drinking.

Objective

Design

Population

Methods

Main outcome measures

Results

Conclusions

Publications

Systematic review of the fetal effects of prenatal binge-drinking.

Similar Datasets

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