Ontology highlight
ABSTRACT:
SUBMITTER: Xu B
PROVIDER: S-EPMC2467387 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Xu Bing B Qu Xiaoling X Gu Shi S Doughman Yong-Qiu YQ Watanabe Michiko M Dunwoodie Sally L SL Yang Yu-Chung YC
Developmental biology 20080226 1
Lung maturation at the terminal sac stage of lung development is characterized by a coordinated increase in terminal sac formation and vascular development in conjunction with the differentiation of alveolar type I and type II epithelial cells. The Cited2-Tcfap2a/c complex has been shown to activate transcription of Erbb3 and Pitx2c during mouse development. In this study, we show that E17.5 to E18.5 Cited2-null lungs had significantly reduced terminal sac space due to an altered differentiation ...[more]