RNA folding: conformational statistics, folding kinetics, and ion electrostatics.
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ABSTRACT:
SUBMITTER: Chen SJ
PROVIDER: S-EPMC2473866 | biostudies-literature | 2008
REPOSITORIES: biostudies-literature
Publications
RNA folding: conformational statistics, folding kinetics, and ion electrostatics.
Annual review of biophysics 20080101
RNA folding is a remarkably complex problem that involves ion-mediated electrostatic interaction, conformational entropy, base pairing and stacking, and noncanonical interactions. During the past decade, results from a variety of experimental and theoretical studies pointed to (a) the potential ion correlation effect in Mg2+-RNA interactions, (b) the rugged energy landscapes and multistate RNA folding kinetics even for small RNA systems such as hairpins and pseudoknots, (c) the intraloop interac ...[more]
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