Ontology highlight
ABSTRACT:
SUBMITTER: Jiang W
PROVIDER: S-EPMC2475707 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Jiang Wei W Betson Martha M Mulloy Roseann R Foster Rosemary R Lévay Magdolna M Ligeti Erzsébet E Settleman Jeffrey J
The Journal of biological chemistry 20080523 30
The Rho GTPases are critical regulators of the actin cytoskeleton and are required for cell adhesion, migration, and polarity. Among the key Rho regulatory proteins in the context of cell migration are the p190 RhoGAPs (p190A and p190B), which function to modulate Rho signaling in response to integrin engagement. The p190 RhoGAPs undergo complex regulation, including phosphorylation by several identified kinases, interactions with phospholipids, and association with a variety of cellular protein ...[more]