Ontology highlight
ABSTRACT:
SUBMITTER: Cheng XW
PROVIDER: S-EPMC2475774 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Cheng Xian Wu XW Murohara Toyoaki T Kuzuya Masafumi M Izawa Hideo H Sasaki Takeshi T Obata Koji K Nagata Kohzo K Nishizawa Takao T Kobayashi Masakazu M Yamada Takashi T Kim Weon W Sato Kohji K Shi Guo-Ping GP Okumura Kenji K Yokota Mitsuhiro M
The American journal of pathology 20080626 2
The elastolytic activity of cathepsins in the myocardium is implicated in hypertensive heart failure (HF). Given that reactive oxygen species are also implicated in protease activation associated with cardiac remodeling, we examined the role of the reactive oxygen species-induced cathepsin activation system in cardiac remodeling during the development of hypertensive HF. Dahl salt-sensitive hypertensive rats maintained on a high-salt diet were treated with vehicle, the cathepsin inhibitor E64d, ...[more]