High impulsivity predicts the switch to compulsive cocaine-taking.
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ABSTRACT:
SUBMITTER: Belin D
PROVIDER: S-EPMC2478705 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Publications
High impulsivity predicts the switch to compulsive cocaine-taking.
Belin David D Mar Adam C AC Dalley Jeffrey W JW Robbins Trevor W TW Everitt Barry J BJ
Science (New York, N.Y.) 20080601 5881
Both impulsivity and novelty-seeking have been suggested to be behavioral markers of the propensity to take addictive drugs. However, their relevance for the vulnerability to compulsively seek and take drugs, which is a hallmark feature of addiction, is unknown. We report here that, whereas high reactivity to novelty predicts the propensity to initiate cocaine self-administration, high impulsivity predicts the development of addiction-like behavior in rats, including persistent or compulsive dru ...[more]
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