The nature of nurture: a genomewide association scan for family chaos.

ABSTRACT: Widely used measures of the environment, especially the family environment of children, show genetic influence in dozens of twin and adoption studies. This phenomenon is known as gene-environment correlation in which genetically driven influences of individuals affect their environments. We conducted the first genome-wide association (GWA) analysis of an environmental measure. We used a measure called CHAOS which assesses 'environmental confusion' in the home, a measure that is more strongly associated with cognitive development in childhood than any other environmental measure. CHAOS was assessed by parental report when the children were 3 years and again when the children were 4 years; a composite CHAOS measure was constructed across the 2 years. We screened 490,041 autosomal single-nucl

SUBMITTER: Butcher LM 

PROVIDER: S-EPMC2480594 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature