Heterogeneity and clinical significance of ETV1 translocations in human prostate cancer.
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ABSTRACT:
SUBMITTER: Attard G
PROVIDER: S-EPMC2480965 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Publications
Heterogeneity and clinical significance of ETV1 translocations in human prostate cancer.
Attard G G Clark J J Ambroisine L L Mills I G IG Fisher G G Flohr P P Reid A A Edwards S S Kovacs G G Berney D D Foster C C Massie C E CE Fletcher A A De Bono J S JS Scardino P P Cuzick J J Cooper C S CS
British journal of cancer 20080701 2
A fluorescence in situ hybridisation (FISH) assay has been used to screen for ETV1 gene rearrangements in a cohort of 429 prostate cancers from patients who had been diagnosed by trans-urethral resection of the prostate. The presence of ETV1 gene alterations (found in 23 cases, 5.4%) was correlated with higher Gleason Score (P=0.001), PSA level at diagnosis (P=<0.0001) and clinical stage (P=0.017) but was not linked to poorer survival. We found that the six previously characterised translocation ...[more]
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