Ontology highlight
ABSTRACT:
SUBMITTER: Rosenzweig R
PROVIDER: S-EPMC2481239 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Rosenzweig Rina R Osmulski Pawel A PA Gaczynska Maria M Glickman Michael H MH
Nature structural & molecular biology 20080530 6
The 26S proteasome is a multisubunit enzyme composed of a cylindrical catalytic core (20S) and a regulatory particle (19S) that together perform the essential degradation of cellular proteins tagged by ubiquitin. To date, however, substrate trajectory within the complex remains elusive. Here we describe a previously unknown functional unit within the 19S, comprising two subunits, Rpn1 and Rpn2. These toroids physically link the site of substrate recruitment with the site of proteolysis. Rpn2 int ...[more]