Ontology highlight
ABSTRACT:
SUBMITTER: Zarrine-Afsar A
PROVIDER: S-EPMC2481363 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Zarrine-Afsar Arash A Wallin Stefan S Neculai A Mirela AM Neudecker Philipp P Howell P Lynne PL Davidson Alan R AR Chan Hue Sun HS
Proceedings of the National Academy of Sciences of the United States of America 20080714 29
Many experimental and theoretical studies have suggested a significant role for nonnative interactions in protein folding pathways, but the energetic contributions of these interactions are not well understood. We have addressed the energetics and the position specificity of nonnative hydrophobic interactions by developing a continuum coarse-grained chain model with a native-centric potential augmented by sequence-dependent hydrophobic interactions. By modeling the effect of different hydrophobi ...[more]