Unknown

Dataset Information

0

Identification of a population of sleep-active cerebral cortex neurons.


ABSTRACT: The presence of large-amplitude, slow waves in the EEG is a primary characteristic that distinguishes cerebral activity during sleep from that which occurs during wakefulness. Although sleep-active neurons have been identified in other brain areas, neurons that are specifically activated during slow-wave sleep have not previously been described in the cerebral cortex. We have identified a population of cells in the cortex that is activated during sleep in three mammalian species. These cortical neurons are a subset of GABAergic interneurons that express neuronal NOS (nNOS). Because Fos expression in these sleep-active, nNOS-immunoreactive (nNOS-ir) neurons parallels changes in the intensity of slow-wave activity in the EEG, and these neurons are innvervated by neurotransmitter systems previously implicated in sleep/wake control, cortical nNOS-ir neurons may be part of the neurobiological substrate that underlies homeostatic sleep regulation.

SUBMITTER: Gerashchenko D 

PROVIDER: S-EPMC2481371 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature

altmetric image

Publications

Identification of a population of sleep-active cerebral cortex neurons.

Gerashchenko Dmitry D   Wisor Jonathan P JP   Burns Deirdre D   Reh Rebecca K RK   Shiromani Priyattam J PJ   Sakurai Takeshi T   de la Iglesia Horacio O HO   Kilduff Thomas S TS  

Proceedings of the National Academy of Sciences of the United States of America 20080721 29


The presence of large-amplitude, slow waves in the EEG is a primary characteristic that distinguishes cerebral activity during sleep from that which occurs during wakefulness. Although sleep-active neurons have been identified in other brain areas, neurons that are specifically activated during slow-wave sleep have not previously been described in the cerebral cortex. We have identified a population of cells in the cortex that is activated during sleep in three mammalian species. These cortical  ...[more]

Similar Datasets

| S-EPMC2913678 | biostudies-literature
| S-EPMC4431668 | biostudies-literature
| S-EPMC5547576 | biostudies-literature
| S-EPMC5406440 | biostudies-literature
| S-EPMC2872647 | biostudies-literature
| S-EPMC2853270 | biostudies-literature
| S-EPMC5456108 | biostudies-literature
| S-EPMC4688141 | biostudies-literature
| S-EPMC4104757 | biostudies-literature
| S-EPMC1158077 | biostudies-other