Ontology highlight
ABSTRACT:
SUBMITTER: Hauri-Hohl MM
PROVIDER: S-EPMC2481556 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Hauri-Hohl Mathias M MM Zuklys Saulius S Keller Marcel P MP Jeker Lukas T LT Barthlott Thomas T Moon Anne M AM Roes Jürgen J Holländer Georg A GA
Blood 20080512 3
The thymus constitutes the primary lymphoid organ responsible for the generation of naive T cells. Its stromal compartment is largely composed of a scaffold of different subsets of epithelial cells that provide soluble and membrane-bound molecules essential for thymocyte maturation and selection. With senescence, a steady decline in the thymic output of T cells has been observed. Numeric and qualitative changes in the stromal compartment of the thymus resulting in reduced thymopoietic capacity h ...[more]