Ontology highlight
ABSTRACT:
SUBMITTER: Nakao S
PROVIDER: S-EPMC2483522 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Nakao Shinsuke S Platek Anna A Hirano Shinji S Takeichi Masatoshi M
The Journal of cell biology 20080721 2
OL-protocadherin (OL-pc) is a transmembrane protein belonging to the cadherin superfamily, which has been shown to accumulate at cell-cell contacts via its homophilic interaction, but its molecular roles remain elusive. In this study, we show that OL-pc bound Nck-associated protein 1 (Nap1), a protein that regulates WAVE-mediated actin assembly. In astrocytoma U251 cells not expressing OL-pc, Nap1 was localized only along the lamellipodia. However, exogenous expression of OL-pc in these cells re ...[more]